The Daytime-Nighttime Appliance (DNA Appliance) is a removable dental appliance used to treat a variety of oral problems. Patients use the appliance during the evening and nighttime (during the body’s natural circadian rhythm). The treatment activates naturally occurring genes to correct underdevelopment in the craniofacial region.The appliance gently expands the upper arch space in 3 dimensions leading to an increase in the size of the nasal cavity. As the upper arch widens, the lower jaw is moved forward to a more natural position.This pulls the tongue and soft tissues to increase the size of the airway and improve a patient’s breathing ability.